Medschool MCQ2: Hypersegmented neutrophils are present in Which of the following anaemia?

Medschool MCQ2:

Hypersegmented neutrophils are present in Which of the following anaemia?

a) Hemolytic

b) Iron deficiency

c) Megaloblastic

d) Aplastic

Explanation:

The correct answer is Megaloblastic anaemia(c).

Megaloblastic anaemia is a maturation disorder of blood cells,there is presence of nucleocytoplasmic asynchrony. That means the maturation lags behind the cytoplasmic maturation!!

Peripheral blood film shows:

1) RBC: Macroovalocytes present with anisocytosis .

2) WBC: Presence of hypersegmented neutrophils.Either >5% neutrophils with at least 5lobes or single neutrophil with 6lobes.

3) Bone marrow: Hypercellular,dyserythropoiesis,giant metamyelocyte,nucleocytoplasmic asynchrony,late-intermediate-early megaloblast.

Reticulocyte count is generally decreased.

In iron deficiency anaemia,microcytic hypochromic RBCs ,leptocytes noted.