Found in a Papillary carcinoma thyroid slide!!!!

Yesterday while reviewing the slides of a Papillary carcinoma thyroid  these cells were found adjacent to normal thyroid tissue.

Initially I thought ....what are these cells??

But after some time I realized that these are the clear cells of Parathyroid gland!!!

So...it is the best time to have a look at the histology of Parathyroid gland.

Histology of Parathyroid gland:

• Composed primarily of chief cells and fat with thin fibrous capsule dividing gland into lobules

• May have a pseudofollicle pattern resembling thyroid follicles (pink material is PAS positive)

Chief cells:

• 6 - 8 microns, polygonal, central round nuclei, contain granules of parathyroid hormone (PTH)

• Basic cell type, other cell types are due to differences in physiologic activity

• 80% of chief cells have intracellular fat

• Chief cell is most sensitive to changes in ionized calcium

Oxyphil cells:

• Slightly larger than chief cell (12 microns), acidophilic cytoplasm due to mitochondria

• No secretory granules

• First appear at puberty as single cells, then pairs, then nodules at age 40

Water clear cell:

• Abundant optically clear cytoplasm and sharply defined cell membranes

• Chief cells with excessive cytoplasmic glycogen.

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