Melanosis coli:
Melanosis coli, also pseudomelanosis coli, is a disorder of pigmentation of the wall of the colon, often identified at the time of colonoscopy. It is benign, and may have no significant correlation with disease. The brown pigment is lipofuscin in macrophages, not melanin.The most common cause of melanosis coli is the extended use of laxatives, and commonly anthraquinone containing laxatives such as Senna and other plant glycosides.On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
Melanosis coli, also pseudomelanosis coli, is a disorder of pigmentation of the wall of the colon, often identified at the time of colonoscopy. It is benign, and may have no significant correlation with disease. The brown pigment is lipofuscin in macrophages, not melanin.The most common cause of melanosis coli is the extended use of laxatives, and commonly anthraquinone containing laxatives such as Senna and other plant glycosides.On biopsy, melanosis coli shows characteristic pigment-laden macrophages within the mucosa on PAS staining.
Comments
Post a Comment
Thank you for posting your comment.Your question will be answered soon.