Cryptococcal meningitis
Cryptococcal meningitis:
The organisms have a mucopolysaccharide capsule. Note the characteristic thinnecked budding (arrow; Papanicolaou stain).CSF sample.
Cryptococcal Meningitis:
The only organism that is identified cytologically with any frequency in CSF is Cryptococcus neoformans, which causes disease in people who are both healthy and immunocompromised. The degree of inflammation is variable.There can be a marked lymphocytic or monocytic pleocytosis, inwhich case organisms are hard to identify. Alternatively, there may be abundant organisms and little inflammatory response. C. neoformans is sometimes
perfectly round, but often indented. The indentations trap air under the coverslip, resulting in a crystal-like refractile artifact.
Cytomorphology of cryptococcal meningitis:
• round yeast forms
• variable size: 5 to 15 μm diameter
• pink or purple (Papanicolaou stain)
• asymmetric, narrow-based budding
• mucin-positive capsule
• refractile artifact
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The organisms have a mucopolysaccharide capsule. Note the characteristic thinnecked budding (arrow; Papanicolaou stain).CSF sample.
Cryptococcal Meningitis:
The only organism that is identified cytologically with any frequency in CSF is Cryptococcus neoformans, which causes disease in people who are both healthy and immunocompromised. The degree of inflammation is variable.There can be a marked lymphocytic or monocytic pleocytosis, inwhich case organisms are hard to identify. Alternatively, there may be abundant organisms and little inflammatory response. C. neoformans is sometimes
perfectly round, but often indented. The indentations trap air under the coverslip, resulting in a crystal-like refractile artifact.
Cytomorphology of cryptococcal meningitis:
• round yeast forms
• variable size: 5 to 15 μm diameter
• pink or purple (Papanicolaou stain)
• asymmetric, narrow-based budding
• mucin-positive capsule
• refractile artifact
If you like, you can visit our youtube channel and facebook page👇🏻
Youtube channel link-https://m.youtube.com/channel/UCPGvHc5Ttw4EtB72WVMiYSw/videos
Facebook page link-https://m.facebook.com/PathologyDiscussionForum/?ref=bookmarks
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