Sea Blue Histiocytes
Sea Blue Histiocytes :
Sea Blue Histiocytes are large lipid-containing histiocytes in the bone marrow which stain sea blue in color. They may be found in a rare autosomal condition characterized by neurological impairment and splenomegaly. Sea-blue–colored histiocytes have been described in the setting of high rates of intramedullary cell death due to lipid storage diseases (e.g. Niemann-Pick disease), myelodysplastic syndromes (MDS), lymphomas, chronic myeloid leukemia, idiopathic thrombocytopenic purpura, autoimmune neutropenia, total parenteral nutrition and β-thalassemia major.
Sea-blue histiocytes are a common cytological feature in the bone marrow of patients with MDS. As other disorders frequently associated with marrow sea-blue histiocytes are relatively rare, MDS is probably the most common cause of this phenomenon in a northern European population. The occasional sea-blue histiocyte may be a normal finding.
If you like, you can visit our youtube channel and facebook page👇🏻
Youtube channel link-https://m.youtube.com/channel/UCPGvHc5Ttw4EtB72WVMiYSw/videos
Facebook page link-https://m.facebook.com/PathologyDiscussionForum/?ref=bookmarks
Sea Blue Histiocytes are large lipid-containing histiocytes in the bone marrow which stain sea blue in color. They may be found in a rare autosomal condition characterized by neurological impairment and splenomegaly. Sea-blue–colored histiocytes have been described in the setting of high rates of intramedullary cell death due to lipid storage diseases (e.g. Niemann-Pick disease), myelodysplastic syndromes (MDS), lymphomas, chronic myeloid leukemia, idiopathic thrombocytopenic purpura, autoimmune neutropenia, total parenteral nutrition and β-thalassemia major.
Sea-blue histiocytes are a common cytological feature in the bone marrow of patients with MDS. As other disorders frequently associated with marrow sea-blue histiocytes are relatively rare, MDS is probably the most common cause of this phenomenon in a northern European population. The occasional sea-blue histiocyte may be a normal finding.
If you like, you can visit our youtube channel and facebook page👇🏻
Youtube channel link-https://m.youtube.com/channel/UCPGvHc5Ttw4EtB72WVMiYSw/videos
Facebook page link-https://m.facebook.com/PathologyDiscussionForum/?ref=bookmarks
Comments
Post a Comment
Thank you for posting your comment.Your question will be answered soon.